SCRN2 is a member of the secernin family, which also includes SCRN1 and SCRN3.[5, 6] Emerging evidence has shown that SCRN1 acts as a regulator of exocytosis,[7] axonal regeneration,[8] and dynamic endoplasmic reticulum remodeling,[9] and that its deregulation contributes to the pathogenesis of Alzheimer's disease and human cancer.[8, 10, 11, 12, 13, 14, 15] SCRN3 also involved in thermal nociception in response to inflammatory stimuli.[16] Comparatively, SCRN2 is a poorly characterized gene. The gene discussed is SCRN2; the disease is early-onset autosomal dominant Alzheimer disease.