Available evidence shows that SCRN2 possesses an electrophilic N‐terminal glyoxylyl (Glox) group that acts as an electrophilic cofactor.[5] In addition, SCRN2 is a potential candidate susceptibility gene for the Alzheimer's disease and respiratory infectious diseases.[17, 18] However, the functional and mechanistic roles of SCRN2 in human cancer remain unclear. Here, SCRN2 is linked to early-onset autosomal dominant Alzheimer disease.