CXCR1 and acute respiratory distress syndrome: FcγRIIa also mediates the biological activities of anti‐IL‐8/IL‐8 complexes in vitro.[171] Elevated IL‐8 levels in lung fluids are recognized as key prognostic indicators of ARDS outcomes.[172] IL‐8 serves as a chemotactic factor, stimulating PMN chemotaxis and degranulation through CXCR1 and CXCR2 receptors.[173] Increased IL‐8 levels have been observed in multiple TRALI cases, positioning it as a risk factor.[27, 33] Blocking CXCR1/2 receptors may suppress PMN chemotaxis and degranulation, thereby counteracting TRALI.