Genomic instability is a hallmark of tumor cells, contributing to aberrant cell cycle control and indeterminate proliferation through the dysregulation of essential cellular pathways.[4] The spindle assembly checkpoint (SAC) has been reported as a critical biological function to ensure accurate chromosome segregation in mitosis and prevent genomic instability.[5] Targeting SAC proteins could induce high levels of genomic instability and aneuploidy that tumor cells cannot tolerate, ultimately leading to senescence and apoptosis.[6]. The gene discussed is ADCY10; the disease is neoplasm.