There was a trend towards increased IFN-γ production in P1 (P = 0.632) following IL-12 (TH1) stimulation in naïve CD4+ T cells when compared to HD; however, this was normal in secretion in the same culture, as well as in production and secretion in CD4+ memory T cells (Fig. 6A–D). Here, IFNG is linked to Huntington disease.