In addition to the 129 strain, the FVB mouse strain has been shown to be resistant to β-aminopropionitrile–induced vascular rupture, and informatively this background also carries the same protective c.G227A allele at the Map2k6 locus, suggesting a role for Map2k6 activity in the pathogenesis of other models of aortic dissection/rupture (Ensembl database) (28). This evidence concerns the gene MAP2K6 and Aortic dissection.