MGMT and brain neoplasm: Furthermore,we compared the cytotoxic effects of compound 1 on variouswild-type brain tumor cell lines, including U87MG, PT#3, LN229 GBMcells, and CT-2A mouse astrocyte cell line as well as TMZ-resistantvariants cell lines, including U87MG-R, PT#3-R, CT-2A-R, and T98G(MGMT-positive).