The breadth of splicing dysregulation within the DM1 cohort is further demonstrated via visualization of select disease-specific events, including CLCN1 exon 7a (e7a), CACNA1S e29, INSR e11, ATP2A1 e22, and MBNL1 e5 (Figure 1D) (14–18, 20, 37–39). This evidence concerns the gene INSR and myotonic dystrophy type 1.