CGAS and viral infectious disease: To further confirm the role of NS3 in cGAS degradation during virus infection, HEK-293T cells were transfected with a plasmid encoding cGAS and infected with BTV-8 ΔNS3, a reverse genetic BTV-8 with a defective NS3 encoding segment, or its reverse genetic BTV-8 control (Rg BTV-8) and mock-infected.