SCN3A and peripheral nerve injury: This might play a role in neuropathic pain, as—though only marginally expressed in C- and Aδ-fibers—some studies suggest that Nav1.3 is upregulated in spinal cord injuries or peripheral nerve injuries in rodents and therefore increases excitability (Hains et al., 2003; Hains et al., 2004; Lampert et al., 2006).