Our study analyzed the correlation between CXCR5 methylation levels in the peripheral blood of patients with SLE and clinical indicators including ESR, CRP, anti‐double stranded DNA (anti‐dsDNA) antibody, complement components 3 (C3) and C4, and 24‐h urinary total protein. Here, CXCR5 is linked to systemic lupus erythematosus.