A major advantage of using GnRH antagonist and PPOS protocols inwomen who are considered fertile is the possibility of preventing OHSS (Al-Inany et al., 2016; Guan et al., 2021) bytriggering ovulation with a GnRH agonist (Youssefet al., 2014; Kalafat et al., 2022). This evidence concerns the gene GNRH1 and ovarian hyperstimulation syndrome.