Many studies suggest that the FMR1 gene is about 6 % of POF cases (Nagarathinam et al., 2021).The FMR1 gene is involved in three different syndromes: fragile X syndrome, POF, andFragile X-associated tremor/ataxia syndrome (FXTAS) at an older age (Oostra & Willemsen, 2003). Here, FMR1 is linked to fragile X syndrome.