In summary, it is already established that: (1) genetic activation of PIK3CD causes immunodeficiency without disordered growth, while (2) inhibition of PIK3R1 recruitment to RTKs and their substrates impairs growth and insulin action, without immunodeficiency, despite all catalytic subunits being affected and (3) loss of p85α alone causes immunodeficiency. Here, INS is linked to Immunodeficiency.