Whereas ACE2 is a critical enzyme in the conversion of angiotensin II (AngII) to angiotensin 1-7 (Ang1-7), down-regulation of ACE2 and an imbalance between AngII and Ang1-7 may directly contribute to the excessive elevation of blood pressure during the acute phase of SARS-CoV-2 infection and after COVID-19 vaccination [70]. Here, ACE2 is linked to COVID-19.