The TYK2:p.Pro1104Ala variant notably confers protection against autoinflammation in more than 10 autoimmune diseases including autoimmune thyroid disease, ankylosing spondylitis, Crohn's disease, psoriasis, systemic lupus erythematosus, rheumatoid arthritis (RA), sarcoidosis, systemic lupus erythematosus, type 1 diabetes (T1D), multiple sclerosis (MS), inflammatory bowel disease and ulcerative colitis [1, 2, 3, 4, 5, 6, 7, 8, 16]. The gene discussed is TYK2; the disease is inflammatory bowel disease.