The TYK2:p.Pro1104Ala variant notably confers protection against autoinflammation in more than 10 autoimmune diseases including autoimmune thyroid disease, ankylosing spondylitis, Crohn's disease, psoriasis, systemic lupus erythematosus, rheumatoid arthritis (RA), sarcoidosis, systemic lupus erythematosus, type 1 diabetes (T1D), multiple sclerosis (MS), inflammatory bowel disease and ulcerative colitis [1, 2, 3, 4, 5, 6, 7, 8, 16]. Here, TYK2 is linked to systemic lupus erythematosus.