As the proportion of lung Foxp3+CD4+ T cells in CD45+ cells positively correlated with day 21 tumor weight (data not shown), depletion of Foxp3+CD4+ T cells by anti-CD4 antibody likely has a stronger effect in augmenting the immune response for the >600 mg tumor than the 95–600 mg tumor group. Here, FOXP3 is linked to neoplasm.