Figure 1B shows representative images of CD31 staining from a different experiment. Twelve models were classified as MVD(IHC)-high or MVD(IHC)-low by top quartile of mean MVD(IHC) values of each tumor model, and LEN showed stronger antitumor activity measured as ΔT/C at day 15 in tumor models with higher MVD(IHC) values (P = 0.038, Welch t test; Fig. 1C). The gene discussed is PECAM1; the disease is neoplasm.