Overall, these observations might suggest that the inflammatory state, caused by both disease and/or aging (mean ± SD for age: 50 ± 14.1 in r‐axSpA; 55 ± 14.0 in PsA; 56 ± 13.6 in RA; and 51 ± 15.0 in HD), has a stronger impact on the basal migratory capabilities of CD8+ than CD4+ T cells. The gene discussed is CD8A; the disease is Huntington disease.