SOX2 and breast cancer: Interestingly, a recent customized machine-learning workflow trained to identify BC in tissue sections using a histological stain compatible with high-dimensional cytometry (BAIDEN), reported that BC express proteins associated with progenitor-cell identity (e.g., vimentin, SOX2, CD133, and EGFR) rather than mature-cell identity (e.g., β-III-tubulin, SMI-311, GFAP, and EAAT1), which tended to be decreased (Arceneaux et al., 2024).