Recently, using snRNA-seq from 53 different AD brain tissue cohorts, Yu et al. (2024) identified in astrocytes a group of neurotoxic markers, ZEP36L, AEBP1, WWTR1, PHYHD1, DST, and RASL12, closely related to disease severity, and involved in inflammatory responses and in pathways related to neuron survival. Here, WWTR1 is linked to Alzheimer disease.