Secreted enzymes such as α1-21 antichymotrypsin, α2-macroglobulin and apolipoprotein J help in Aβ catabolism in the parenchyma (Ries and Sastre, 2016; Carter et al., 2019), and anti-inflammatory cytokines such as tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), soluble intercellular adhesion molecule 1 (sICAM-1), and transforming growth factor beta (TGFβ) influence plaque clearance in a rat model of AD (Chen et al., 2015; Saha et al., 2020). This evidence concerns the gene CLU and Alzheimer disease.