GFAP and Alzheimer disease: In a 3xTg-AD mouse model, the PDAPP-J20 transgenic mice, and in adult mice intravenously injected with Aβ oligomers, astrocyte atrophy, characterized by reduced GFAP intensity, decrease in the number of astrocyte branches, and a reduction in the area covered by them, was observed in several brain regions, including the entorhinal cortex, medial prefrontal cortex, dentate gyrus, and hippocampal CA1, during the early stages of AD and along with disease progression (Olabarria et al., 2010; Kulijewicz-Nawrot et al., 2012; Beauquis et al., 2013).