Genetic factors including variations in some specific genes such as MTHFR, MTHFD1, MTRR, VANGL1, VANGL2, CELSR1, and FUZ, as well as variants in the T-locus on chromosome 6q have also been studied in the development of spina bifida and other spinal dysmorphisms [7]. Here, VANGL2 is linked to spina bifida.