Gingerol138 (137) has the capacity to induce the generation of reactive oxygen species (ROS) in chronic (K562) and acute myeloid leukemia (U937) tumor cell lines, resulting in the disruption of the G2/M cell cycle, a reduction in cell cycle protein expression (including cyclin B1, Cdk1, Cdc25B, and Cdc25C), and alterations in cellular oxidant status that promote mitochondrial ROS production. Here, CDK1 is linked to neoplasm.