DPP4 and non-small cell lung carcinoma: Apigenin-induced cell cycle arrest and apoptosis by regulating the expression of Bcl-2.106 Additionally, apigenin (3 mg kg−1) inhibited NSCLC xenograft growth and metastasis by targeting the dipeptidyl peptidase IV (DPPIV) enzyme.107 Digoxin anticancer activity against human lung cancer was investigated in BALB/c nude mouse xenograft model.