CASP3 and leukemia: Bulbispermine (37) showed anticancer activity against glioblastoma and leukemia by inhibiting apoptosis resistance.25 Distichamine (38) in leukemia alter the cell cycle and induce death by activating the caspase 3 and 7.50 lycorine (39) and amarbellisine (40) reduce Mcl-1 at the translational level, which causes cell death in leukemia cells.