Furthermore, astragalin-induced cell death is associated with a time- and dose-dependent increase in the Bax/Bcl-2 ratio, as well as increased cleavage of caspase-3/-9 and PARP123 Ginkgetin (122) decreased cell viability in breast cancer and blocked estrogen receptor (ER) expression at mRNA and protein levels. Here, ESR1 is linked to breast carcinoma.