Linalool also upregulated p53 and cyclin-dependent kinase inhibitors, which induced strong apoptosis in a variety of leukemia cells.147 By decreasing the mRNA and protein expression of human telomerase reverse transcriptase, costunolide (117) inhibited proliferation in human B cell leukemia cells148 acacetin (118) inhibited epidermal growth factor (EGF)-induced cell transformation and phosphorylation of p70S6K. This evidence concerns the gene EGF and leukemia.