AKT1 and neoplasm: Tetrandrine's anticancer properties may be linked to autophagy, cell cycle arrest, alleviate metastasis and suppression of tumor cell proliferation.55 Piplartine (46) caused G2/M cell cycle arrest, followed by mitochondrial-dependent apoptosis, as shown by chromatin condensation and inter-nucleosomal DNA breakage.56 Plumbagin (47) showed its anticancer potential through the NF-k, STAT3, and Akt regulatory signaling pathways.