Studies have revealed that the hypomethylation of global genomic DNA and many immune-related genes in SLE CD4+ T cells result in the overexpression of growth arrest and DNA damage inducible 45 alpha (Gadd45a), CD70, CD11a, CD40L, and perforin, thereby contributing to autoimmunity (12–17). Here, GADD45A is linked to Autoimmunity.