GADD45A and systemic lupus erythematosus: Studies have revealed that the hypomethylation of global genomic DNA and many immune-related genes in SLE CD4+ T cells result in the overexpression of growth arrest and DNA damage inducible 45 alpha (Gadd45a), CD70, CD11a, CD40L, and perforin, thereby contributing to autoimmunity (12–17).