found that downregulation of ubiquitin-like with PHD and RING finger domains 1 (UHRF1) in the T follicular helper (Tfh) cells of SLE patients, decreased UHRF1 can reduce DNA methylation and H3K27me3 levels in the B cell lymphoma 6 (BCL6) promoter region, which resulted in the increased level of BCL6 and accelerated differentiation of Tfh cells (24). The gene discussed is UHRF1; the disease is systemic lupus erythematosus.