Inhibiting pro-inflammatory cytokines and factors associated with renal fibrosis in human renal glomerular endothelial cells.Attenuating LN by targeting transforming growth factor beta receptor 1 (Tgfbr1), an enhancer of the TGF-β/Smad/TLR3 pathway. The gene discussed is TGFB1; the disease is renal fibrosis.