MAP4K1 and systemic lupus erythematosus: Studies have found that the reduction of jumonji domain-containing 3 (JMJD3) at the hematopoietic progenitor kinase 1 (HPK1) promoter increased H3K27me3, leading to the reduced mixed-lineage leukemia 1 and H3K4me3 abundance in Tfh cells of SLE patients.