found that the expression of miR-301a-3p is significantly increased in SLE PBMCs, promoting the expression of IL-6, IL-17, and interferon-γ (INF-γ), as well as IL-1 receptor-associated kinase 1 (IRAK1)-mediated Th17 cell differentiation by targeting Pellino 1 (Peli1) (49). Here, PELI1 is linked to systemic lupus erythematosus.