S100A8 and systemic lupus erythematosus: Gao reported that in identifying feature autophagy-related genes (ARGs) in SLE PBMCs, the cg24898863 (S100A8) gene was hypomethylated and upregulated, whereas the cg27490128 (NCR3) gene was hypermethylated and downregulated, prompting the possible mechanism of ARGs involved in the process of SLE (20).