In terms of innate immunity, upregulation of miR-210-5p in macrophages from SLE patients can inhibit specificity protein 1 (SP1)- and HSCARG-mediated NADPH oxidase (NOX) activity and reactive oxygen species production, leading to the accumulation of secondary necrotic cells, which is involved in the pathogenesis of SLE (53). This evidence concerns the gene SP1 and systemic lupus erythematosus.