NMRAL1 and systemic lupus erythematosus: In terms of innate immunity, upregulation of miR-210-5p in macrophages from SLE patients can inhibit specificity protein 1 (SP1)- and HSCARG-mediated NADPH oxidase (NOX) activity and reactive oxygen species production, leading to the accumulation of secondary necrotic cells, which is involved in the pathogenesis of SLE (53).