Immune scores obtained through various tools, including xCell and ESTIMATE, while specific immune cell populations such as CD4+ T cells (via EPIC), CD4+ naïve and memory T cells (via ABIS), CD8+ T cells, and macrophages (M0 and M2 types) were assessed using CIBERSORT and CIBERSORT_abs, showing high expression in melanoma samples from the TCGA dataset (Figure 6A). The gene discussed is CD8A; the disease is melanoma.