TLR4 and myocarditis: Remarkably, all the miRs in PEV were reported in the literature to be anti-viral, anti-inflammatory, to inhibit the TLR4/inflammasome pathway, or had been shown to decrease CVB3 myocarditis in an animal model (80, 85–87) (Table 3), which correlates to the global shut-down of myocardial inflammation observed for PEV.