Initially TNF-γ works by recruiting cohorts (CXCL9, CXCL10, CXCL11, and CXCR3) to promote antigen presentation (MHC class I and class II), T-cell initiation and activation (CD80, CD86, and CD40), and tumor cell killing (Fas and FASL). This evidence concerns the gene CD40 and neoplasm.