However, prolonged exposure to interferon-gamma transforms teammates into adversaries, producing pro-tumorigenic effects through immunosuppression (PDL1, IDO1, Fas, and FASL), angiogenesis (CXCL9, CXCL10, CXCL11, IDO1, and iNOS), and tumor cell proliferation (24–26). The gene discussed is IDO1; the disease is neoplasm.