Purified LiTE directed T cells to lyse luciferase-expressing CT26EGFR tumor cells in a dose-dependent manner when in vitro cocultured with murine splenocytes at a E:T ratio of 5:1 [median effective concentration (EC50), 15.4 nM] (Figure 1C), indicating that EGFR cross-linking is required for LiTE-induced cytotoxicity. The gene discussed is EGFR; the disease is neoplasm.