For inducing polyclonal T cell engagement, we designed an albumin-free LiTE molecule with a half-life of 0.59 hours when administered as a purified protein and of 18.9 hours after mRNA-LNP delivery, ensuring a shorter systemic exposure cycle compared to Albu-LiTCo and minimizing on-target off-tumor toxicity. This evidence concerns the gene ALB and neoplasm.