Moreover, among the 657 down-regulated proteins identified, tetranectin (CLEC3B), protein AMBP, ephrin type-B receptor 6 (EPHB6), and vesicular integral-membrane protein VIP36 (LMAN2) have been linked to a decreased risk of eGFR decline in patients with CKD (28). The gene discussed is CLEC3B; the disease is chronic kidney disease.