Focusing on the past 5 years, the top four articles in terms of burst value are: Cruz-Herranz’s et al. (38) proposal for standardizing quantitative optical coherence tomography (OCT) studies, Petzold’s et al. (28) meta-analysis of retinal layer segmentation in multiple sclerosis, Varanita’s et al. (39) work on the role of OPA1 in controlling apoptosis and ischemic tissue damage through mitochondrial cristae remodeling, and Thompson’s et al. (40) revision of multiple sclerosis diagnostic criteria. Here, OPA1 is linked to multiple sclerosis.