TP53 and chronic hepatitis B virus infection: Although previous literature has studied the association between hepatitis C infection and colon adenomas, with the HCV envelope protein E2 stimulating B cell growth and the core protein inhibiting tumor protein p53 (TP53) and activating nuclear factor-kappa beta (NF-κB), resulting in tumor growth, similar studies regarding the relationship between chronic hepatitis B and colorectal neoplasia have yielded inconclusive results [13-15].