PAX8 and carcinoma: Given the strong suspicion of carcinoma, a second liver biopsy was performed, revealing a poorly differentiated carcinoma with the following immunohistochemical profiles: positive markers, Oscar, AE1/AE3, SATB2, and HER2 (3+); negative markers, CK7, CK20, GATA3, CDX2, PAX8, TTF-1, and hormonal receptors; and a PD-L1 score of 5%.