Deficiency in ERCC1 and ERCC2 proteins is connected with the risk of malignancies [57]. Research has shown that individuals with mutations or lower expression levels of ERCC1 and ERCC2 are at an increased risk of developing certain types of cancers, emphasizing the important role these proteins play in maintaining genomic stability and preventing the formation of tumors [57]. This evidence concerns the gene ERCC1 and cancer.