To find all eligible studies of the literature written in the English language on the relationship between germline SNPs of DNA repair genes and glioblastoma risk, we searched the database (up to January 2024) including the Cochrane Library, PubMed, Medline, and Embase, via combinations of the following terms: Brain tumors; glioma; glioblastoma; gene associations; SNPs; XRCC1 gene; XRCC3 gene; ERCC1 gene; ERCC2 gene Furthermore, reference lists of included studies were examined for additional eligible articles. This evidence concerns the gene XRCC1 and brain neoplasm.