Recent study has identified ZNF207 as a putative immunosuppressive target in HCC (21), which demonstrated that ZNF207 protein levels are significantly elevated in HCC tissues, and its expression is associated with several clinical parameters such as cirrhosis, nodule number, tumor capsule presence, vascular invasion, and TNM staging (tumor, Node, Metastasis staging system), all of which are critical factors in the progression and prognosis of HCC (22). This evidence concerns the gene ZNF207 and Cirrhosis.