PPARGC1A and cancer: Consequently, suppression of p53 signaling by miR-122 decreased the expression of TP53 target genes related to mitochondrial homeostasis, like Tfam, Pgc-1a, Sco2, and 16S ribosomal RNA, resulting in impaired energy production in skeletal muscles, promoting muscle deconditioning and cancer-associated cachexia development (101).