CYP7A1 and Disorder of lipid metabolism: Furthermore, it has been demonstrated that saikosaponin A has the capacity to alleviate lipid metabolism disorders in rat liver by stimulating the expression of intracellular lipid and cholesterol catabolism-related genes, including peroxisome proliferator-activated receptor α (PPARα), and cholesterol 7α-hydroxylase-1 (CYP7a1) (52, 53).