TGFB1 and neoplasm: A recent study discovered that ω-6 LCPUFA enriched diet regulated NF-B-p65 levels and activated the transcription factor Yin Yang 1 to upregulate COX-2 and transforming growth factor (TGF)-β, ultimately encouraging a more aggressive tumor phenotype, while ω-3 LCPUFA could reverse these effects.79