IL17A and oral mucositis: It has even been found that long-term use of Tripterygium Glycosides causes skin and mucosal reactions such as oral mucosal ulcers, dryness of the mouth and eyes, roughness and dryness of the skin, rashes, skin sclerosis, and increased melanin production, which is usually associated with the inhibition of the IL-23/IL-17 pathway (Chu et al., 2019; Qin et al., 2018).