In this study, in the hippocampal CA1 region of SAMP8 mice, the fluorescence intensity and protein expression of RAGE increased, LRP1 expression decreased, and Aβ content increased, suggesting that Aβ accumulation in the AD brain may have a relationship with the dysregulation of the RAGE/LRP1 receptor system in the BBB. The gene discussed is AGER; the disease is Alzheimer disease.