Schmitt et al. (2021) proposed electrophiles as a new class of ferroptosis inducers, and unlike BSO and erastin, DMF induces lipid peroxidation and effectively and rapidly depletes GSH by directly inducing succinylation of cysteine residues, thereby promoting ferroptosis. Their research data suggests that the sensitivity of GCB- DLBCL cell lines to DMF-induced ferroptosis is related to their high expression of 5-LOX. Additionally, in ABC-DLBCL cells dependent on NF-κB and STAT3 survival signals, DMF can effectively inhibit the IKK complex’s and Janus kinase’s activity (Schmitt et al., 2021). Here, ALOX5 is linked to diffuse large B-cell lymphoma.