NFE2L2 and diffuse large B-cell lymphoma: Further observation found that low expression of Nrf2 in the nucleus, high expression of Nrf2 in the cytoplasm, low expression of Nrf1 in the nucleus, and low expression of Keap1 in the cytoplasm are all closely related to the poor prognosis of high-risk DLBCL patients (Kari et al., 2019).