Loss of GIPR induced aortic atherosclerosis and inflammation in ApoE−/−:Gipr−/− high fat diet-fed mice despite a reduced weight gain and preserved glucose homeostasis compared to ApoE−/−:Gipr+/+ mice (87), further confirming the anti- inflammatory role of GIP in atherosclerosis (Figure 2B). This evidence concerns the gene GIPR and atherosclerosis.