By employing different machine learning models, we performed a comprehensive analysis and identified 10 COL1A1hiNR4A1low FB signature genes (COL1A2, EDNRA, PCOLCE2, PCSK6, CRISPLD2, CRYAB, TGFBR3, CDH19, LMCD1, and FKBP5), which have a strong discriminatory potential for IHD and healthy populations. Here, COL1A2 is linked to myocardial ischemia.