Unlike Kosiborod et al., which emphasized patient-reported outcomes (KCCQ-CSS), our study focuses on early-onset post-myocardial infarction HF, highlighting improvements in biomarkers (sST2, NT-proBNP), autonomic function (HRV), echocardiographic parameters, and reduced MACE risk. Here, NPPB is linked to myocardial infarction.