First generation radiotracers such as [18F]AV-1451 and [18F]THK-5351 showed high correspondence with tau pathology distribution at autopsy as well as cognitive performance (Smith et al., 2019; Bucci et al., 2021; Sperling et al., 2018) and performed well at differentiating AD from other non-AD-tauopathies (Ossenkoppele et al., 2018). Here, MAPT is linked to Alzheimer disease.