MAPT and Alzheimer disease: Adults with DS have been reported to exhibit tau tracer binding according to Braak stages (Fleming et al., 2023; Hartley et al., 2022; Rafii et al., 2017), with a similar pattern as in euploid individuals with sporadic rather than autosomal-dominant AD (Mann et al., 1986; Rafii et al., 2017; Mueller et al., 2020; Wisch et al., 2024).