In DS, a study in plasma has found pTau-217 and GFAP consistently positively correlated with increased tau tracer binding in the temporal region of amyloid-positive DS individuals (Janelidze et al., 2022), suggesting the potential for a multimodal approach for increased diagnostic accuracy and ability to monitor disease progression as well as contextualizing tau PET results within the current framework of AD criteria. The gene discussed is GFAP; the disease is Dravet syndrome.