MAPT and Alzheimer disease: Moreover, hippocampal atrophy, one of the most reliable predictor of AD (Bernard et al., 2014; Jack et al., 1998, 2013, 2015) has been related to Tau accumulation in the temporal cortex in TEP imaging studies (Chen et al., 2024; Krishnadas et al., 2022; Park et al., 2019).