After exposure to irradiation or oncogenic transposons, cGAS- and STING-deficient mice show decreased upregulation of SASP factors like interleukin 6 (IL-6), C-X-C motif chemokine ligand (CXCL) 10, and cyclin dependent kinase inhibitor 2A (Cdkn2a) in vivo.21 Furthermore, nuclear programmed death-ligand 1 (PD-L1) silencing in the lung cancer A549 cell line enhances STING promoter activity, upregulates STING expression, induces tumor cell senescence, and inhibits lung cancer growth. This evidence concerns the gene CD274 and lung cancer.