In a notable study, CCR2+ monocytic MDSCs (M-MDSCs) were observed to accumulate in MC38 colon cancer and lewis lung carcinoma (LLC) tumors in a STING-dependent manner following tumor irradiation with a single dose of 20 Gy or intratumoral injection of the STING agonist cGAMP.43 This evidence concerns the gene STING1 and malignant colon neoplasm.