ACTA2 and non-small cell lung carcinoma: NSCLC CAFs 2 closely resembled the myofibroblast-like CAFs described by Lambrechts et al,37 characterized by elevated expression of the activated fibroblast marker actin alpha 2, smooth muscle (ACTA2), the smooth muscle cell marker myosin heavy chain 11 (MYH11), and markers for platelet derived growth factor (PDGF) signaling.