,53 Specifically, CAFs produce key molecules, such as vascular endothelial growth factor A (VEGFA),54 CXCL12,55 FGF2,56,57 and platelet-derived growth factor C (PDGFC),58, 59, 60 to enhance angiogenesis and tumor growth (Table 1). This evidence concerns the gene CXCL12 and neoplasm.