This distribution suggests that p110δ and p110γ play vital roles in both the innate and adaptive immune systems, making them potential targets for PI3K-related drug development.20, 21, 22 PI3K-α, PI3K-γ, and PI3K-δ have been reported to be involved in lung inflammation in conditions such as asthma and COPD.23 This evidence concerns the gene PIK3CD and inflammation.