Post-treatment changes in neurovegetative symptoms of depression were predicted by the pattern of change in both CRP (b = −.0001, t [20] = -2.549, p = .019; model summary: R2 = .695, F [7,20] = 6.513, p < .001) and TNF-α (b = −.004, t [20] = -2.167, p = .043; model summary: R2 = .626, F [7,20] = 4.779, p = .003), such that acute change in CRP or TNF-α differentially predicted change in neurovegetative symptoms based on post-treatment levels of CRP or TNF-α, over and above the effects of age, sex, BMI or baseline/pre-treatment CRP or TNF-α levels. The gene discussed is TNF; the disease is major depressive disorder.