In the OT versus OC comparison (Figure 14) pathways such as “Rap1 signaling pathway”, “MAPK signaling pathway”, “PI3K-Akt signaling pathway”, “p53 signaling pathway”, “hypertrophic cardiomyopathy” and “focal adhesion” were positively enriched, while “calcium signaling pathway”, “axon guidance”, “cAMP signaling pathway” and “lysosome” were negatively enriched. This evidence concerns the gene TP53 and hypertrophic cardiomyopathy.