Recent multicenter study have shown that the expression of N- and E-cadherin are markers for normal hepatocytes and cholangiocytes, respectively, and that the expression of E- and N-cadherin is retained in HCC and intrahepatic cholangiocarcinoma (iCCA) (Gerber et al., 2024; Straub et al., 2011). This evidence concerns the gene CDH1 and hepatocellular carcinoma.